Assignment: Evidence-Based Project, Part 4: Critical Appraisal Of Research
July 12, 2019
HIPAA and Mandated Reporters
July 12, 2019

Estimate the survival (time to progression to hypertension) functions for each treatment group using the Kaplan-Meier approach

A clinical trial is conducted to evaluate the efficacy of a new drug for prevention of
hypertension in patients with pre-hypertension (defined as systolic blood pressure between
120–139 mmHg or diastolic blood pressure between 80–89 mmHg). A total of 20 patients are
randomized to receive the new drug or a currently available drug for treatment of high blood
pressure. Participants are followed for up to 12 months, and time to progression to
hypertension is measured. The experiences of participants in each arm of the trial are shown
below.
data is on the document. the first one

To answer the question as to whether or not there is a difference in time to progression, a
Chi square statistic is computed. The critical value for rejection of the null hypothesis is
3.84. The computed Chi square is 0.335.
Based on comparing the computed Chi square and the critical Chi square, which of the
following is (are) true?
A. There is not statistically significant evidence to show that the time to progression is
different between groups.
B. There is statistically significant evidence to show that the time to progression is
different between groups.
C. The time to progression is essentially the same for each group.
D. a and c.
The hazard ratio risk of progression to hypertension is 0.658. Based on this computation,
which of the following is (are) true?
A. The risk of progression to hypertension is reduced by 34.2% in patients assigned
to the new drug as compared to the currently available drug.
B. The risk of progression to hypertension is 1.52 times higher in patient’s current
drug as compared to the new drug.
C. The risk of progression to hypertension is 5.12 times higher in patient’s current
drug as compared to the new drug
D. a and b

 

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