Do a complete literature search on the Marfan syndrome disease and its related genes.This information MUST be incorporated in the paper.
Search the GenBank database for a set of related entries pertaining to a human disease causes in part by a Single Nucleotide Polymorphism.The best candidates for this study should be genetic variations of the same gene or set of genes.
Determine the important motifs in the DNA sequences (i.e. ORF’s) as well as composition analysis (i.e. GC content)
Search the literature and suggest how these gene’s expression is controlled
Suggest a method for a quick test for identifying individuals that may carry the disease alleles (i.e. RFLP) using both literature and LaserGene methods
Suggest a microarray method for further studying gene expression for this disease (may expand beyond the current gene being analyzed)
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